Dual-network cross-linking is a manufacturing approach in which two distinct cross-linked hyaluronic acid networks — one open and flexible, one dense — are formed and chemically interconnected during reticulation. The finished gel behaves as a single dual-phase matrix that combines the texture of both networks.
In a homogeneous network, cross-linking density is a single setting: increase it and the gel becomes denser and stiffer; decrease it and the gel becomes softer and looser. One network can only sit at one point on that scale.
Build two networks with different architectures — an open, flexible network and a dense network — then interconnect them chemically so they behave as one material. Each network contributes its own texture to the finished gel.
Temperature, pH and ionic strength control where cross-links form and how uniformly each network develops; the interconnection step bonds the two networks into a coherent whole.
PUREMATRIX™ is the dual-network platform used across the Voleria® range. The ratio, density and interconnection of the two networks are calibrated into three consistencies: Voleria Fine (soft), Voleria Mid (balanced) and Voleria Deep (dense).
Published 2026-09-21 · Last updated 2026-09-21